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Dysbiosis is not an answer

Dysbiosis, an imbalance in the microbiota, has been a major organizing concept in microbiome science. Here, we discuss how the balance concept, a holdover from prescientific thought, is irrelevant to — and may even distract from — useful microbiome research.

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References

  1. 1

    Magner, L. N. A History of Medicine (CRC Press, 2005).

    Book  Google Scholar 

  2. 2

    Tamboli, C. P., Neut, C., Desreumaux, P. & Colombel, J. F. Gut 53, 1–4 (2004).

    CAS  Article  Google Scholar 

  3. 3

    Bäumler, A. J. & Sperandio, V. Nature 535, 85–93 (2016).

    Article  Google Scholar 

  4. 4

    Mazmanian, S. K., Round, J. L. & Kasper, D. L. Nature 453, 620–625 (2008).

    CAS  Article  Google Scholar 

  5. 5

    Friedman, J. & Alm, E. J. PLoS Comput. Biol. 8, e1002687 (2012).

    CAS  Article  Google Scholar 

  6. 6

    Fischbach, M. A. & Sonnenburg, J. L. Cell Host Microbe 10, 336–347 (2011).

    CAS  Article  Google Scholar 

  7. 7

    Lee, Y. K. & Mazmanian, S. K. Science 330, 1768–1773 (2010).

    CAS  Article  Google Scholar 

  8. 8

    Sczesnak, A. et al. Cell Host Microbe 10, 260–272 (2011).

    CAS  Article  Google Scholar 

  9. 9

    Caselli, M., Tosini, D., Gafà, R., Gasbarrini, A. & Lanza, G. Am. J. Gastroenterol. 108, 860–861 (2013).

    Article  Google Scholar 

  10. 10

    Henao-Mejia, J. et al. Nature 482, 179–185 (2012).

    CAS  Article  Google Scholar 

  11. 11

    Roberfroid, M. et al. Br. J. Nutr. 104, S1–S63 (2010).

    CAS  Article  Google Scholar 

  12. 12

    Devkota, S. et al. Nature 487, 104–108 (2012).

    CAS  Article  Google Scholar 

  13. 13

    Hopkins, M. J., Sharp, R. & Macfarlane, G. T. Gut 48, 198–205 (2001).

    CAS  Article  Google Scholar 

  14. 14

    Sokol, H. et al. Proc. Natl Acad. Sci. USA 105, 16731–16736 (2008).

    CAS  Article  Google Scholar 

  15. 15

    Harley, I. T. & Karp, C. L. Mol. Metab. 1, 21–31 (2012).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Eric J. Alm.

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Olesen, S., Alm, E. Dysbiosis is not an answer. Nat Microbiol 1, 16228 (2016). https://doi.org/10.1038/nmicrobiol.2016.228

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