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Dysbiosis is not an answer

Dysbiosis, an imbalance in the microbiota, has been a major organizing concept in microbiome science. Here, we discuss how the balance concept, a holdover from prescientific thought, is irrelevant to — and may even distract from — useful microbiome research.

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References

  1. Magner, L. N. A History of Medicine (CRC Press, 2005).

    Book  Google Scholar 

  2. Tamboli, C. P., Neut, C., Desreumaux, P. & Colombel, J. F. Gut 53, 1–4 (2004).

    Article  CAS  Google Scholar 

  3. Bäumler, A. J. & Sperandio, V. Nature 535, 85–93 (2016).

    Article  Google Scholar 

  4. Mazmanian, S. K., Round, J. L. & Kasper, D. L. Nature 453, 620–625 (2008).

    Article  CAS  Google Scholar 

  5. Friedman, J. & Alm, E. J. PLoS Comput. Biol. 8, e1002687 (2012).

    Article  CAS  Google Scholar 

  6. Fischbach, M. A. & Sonnenburg, J. L. Cell Host Microbe 10, 336–347 (2011).

    Article  CAS  Google Scholar 

  7. Lee, Y. K. & Mazmanian, S. K. Science 330, 1768–1773 (2010).

    Article  CAS  Google Scholar 

  8. Sczesnak, A. et al. Cell Host Microbe 10, 260–272 (2011).

    Article  CAS  Google Scholar 

  9. Caselli, M., Tosini, D., Gafà, R., Gasbarrini, A. & Lanza, G. Am. J. Gastroenterol. 108, 860–861 (2013).

    Article  Google Scholar 

  10. Henao-Mejia, J. et al. Nature 482, 179–185 (2012).

    Article  CAS  Google Scholar 

  11. Roberfroid, M. et al. Br. J. Nutr. 104, S1–S63 (2010).

    Article  CAS  Google Scholar 

  12. Devkota, S. et al. Nature 487, 104–108 (2012).

    Article  CAS  Google Scholar 

  13. Hopkins, M. J., Sharp, R. & Macfarlane, G. T. Gut 48, 198–205 (2001).

    Article  CAS  Google Scholar 

  14. Sokol, H. et al. Proc. Natl Acad. Sci. USA 105, 16731–16736 (2008).

    Article  CAS  Google Scholar 

  15. Harley, I. T. & Karp, C. L. Mol. Metab. 1, 21–31 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Eric J. Alm.

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Olesen, S., Alm, E. Dysbiosis is not an answer. Nat Microbiol 1, 16228 (2016). https://doi.org/10.1038/nmicrobiol.2016.228

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  • DOI: https://doi.org/10.1038/nmicrobiol.2016.228

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