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Antimicrobials: Constraints on microbial warfare

Microorganisms produce antibiotics, which can exclude competitors, but bacteria typically only synthesize modest amounts of these compounds. New work suggests this may be an evolutionary strategy to balance the benefits of antimicrobial warfare against inadvertently providing help to resistant free-loaders.

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Figure 1: Trade-offs for antibiotic production.

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Correspondence to William R. Harcombe.

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Chacón, J., Harcombe, W. Antimicrobials: Constraints on microbial warfare. Nat Microbiol 1, 16225 (2016). https://doi.org/10.1038/nmicrobiol.2016.225

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