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Structural biology: Variability without change

Nature Microbiology volume 1, Article number: 16218 (2016) | Download Citation

Sequence variability in microbial surface proteins can be extensive in order to promote immune escape, but the changes must not interfere with the function of the protein. Structural analysis of a streptococcal protein now clarifies how an extremely variable region retains its ability to specifically bind its human target.

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Author information

Affiliations

  1. Gunnar Lindahl is in the Department of Veterinary Disease Biology, University of Copenhagen, 1870 Frederiksberg C, Denmark.

    • Gunnar Lindahl
  2. Jenny J. Persson is in the Department of Experimental Medical Science, Lund University, SE-221 84 Lund, Sweden.

    • Jenny J. Persson

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Corresponding author

Correspondence to Gunnar Lindahl.

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DOI

https://doi.org/10.1038/nmicrobiol.2016.218

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