A small change provides large benefits when combining force spectroscopy and fluorescence-based measurements of single molecules.
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Hohng, S. et al. Fluorescence-force spectroscopy maps two-dimensional reaction landscape of the Holliday junction. Science 318, 279–283 (2007).
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Evanko, D. Fluorescence-force spectroscopy: watch your tether. Nat Methods 4, 986–987 (2007). https://doi.org/10.1038/nmeth1207-986a