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Optogenetics meets optical wavefront shaping

Optogenetic stimulation by ultrashort laser pulses could allow neural circuits in the living brain to be probed with cellular resolution, despite pervasive light scattering. Now sophisticated new multiphoton stimulation systems that strike a better balance between lateral and axial resolution help realize this potential by matching the illumination volume to the soma's dimensions.

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Figure 1: The challenge of optogenetic multiphoton stimulation.


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Correspondence to Shy Shoham.

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Shoham, S. Optogenetics meets optical wavefront shaping. Nat Methods 7, 798–799 (2010).

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