Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Sub-angstrom accuracy in protein loop reconstruction by robotics-inspired conformational sampling

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Loop reconstruction with KIC.
Figure 2: Performance of the KIC loop reconstruction protocol.


  1. Sellers, B.D. et al. Proteins 72, 959–971 (2008).

    Article  CAS  Google Scholar 

  2. Felts, A.K. et al. J. Chem. Theory Comput. 4, 855–868 (2008).

    Article  CAS  Google Scholar 

  3. Go, N. & Scheraga, H.A. Macromolecules 3, 178–187 (1970).

    Article  CAS  Google Scholar 

  4. Coutsias, E.A. et al. Int. J. Quantum Chem. 106, 176–189 (2006).

    Article  CAS  Google Scholar 

  5. Schueler-Furman, O., Wang, C., Bradley, P., Misura, K. & Baker, D. Science 310, 638–642 (2005).

    Article  CAS  Google Scholar 

  6. Canutescu, A.A. & Dunbrack, R.L. Jr . Protein Sci. 12, 963–972 (2003).

    Article  CAS  Google Scholar 

  7. Wang, C., Bradley, P. & Baker, D. J. Mol. Biol. 373, 503–519 (2007).

    Article  CAS  Google Scholar 

Download references


We thank D. Baker and A. Sali for valuable comments, and B. Sellers and M. Jacobson for sharing data and for helpful discussions. This work was supported by grants from the US National Institutes of Health to T.K. (PN2-EY016525) and E.A.C (R01-GM08171), the University of California Lab Research Program (T.K.), and a PhRMA Foundation Predoctoral Fellowship (D.J.M.).

Author information

Authors and Affiliations


Corresponding author

Correspondence to Tanja Kortemme.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–4, Supplementary Tables 1–8, Supplementary Methods, Supplementary Discussion (PDF 3700 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mandell, D., Coutsias, E. & Kortemme, T. Sub-angstrom accuracy in protein loop reconstruction by robotics-inspired conformational sampling. Nat Methods 6, 551–552 (2009).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing