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Prion biology: the quest for the test

The adaptation of the protein misfolding cyclic amplification assay (PMCA) to use recombinant hamster prion protein (PrP) as a substrate shows promise for both basic research applications and clinical diagnostic assays.

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Figure 1: Prion replication and PMCA.


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Aguzzi, A. Prion biology: the quest for the test. Nat Methods 4, 614–616 (2007).

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