Fish fingers on the menu

Zebrafish researchers rejoice! Reverse genetics is now on the menu, thanks to zinc-finger nucleases.

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Figure 1: An example of mutation introduced using ZFNs in a zebrafish embryo and transmitted through the germline.

References

  1. 1

    Doyon Y. et al. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nat. Biotechnol. 26, 702–708 (2008).

  2. 2

    Meng, X. et al. Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases. Nat. Biotechnol. 26, 695–701 (2008).

  3. 3

    Ramirez, C.L. et al. Unexpected failure rates for modular assembly of engineered zinc fingers. Nat. Methods 5, 374–375 (2008).

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Kiermer, V. Fish fingers on the menu. Nat Methods 5, 579 (2008). https://doi.org/10.1038/nmeth0708-579

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