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Getting a DNA to do an RNA's job


The successful in vitro evolution of a DNA enzyme based on a ribozyme could offer insights into early evolutionary events and provide guidelines for designing hardier catalytic oligonucleotides.

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    Paul, N. et al. Conversion of a ribozyme to a deoxyribozyme through in vitro evolution. Chem. Biol. 13, 329–338 (2006).

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