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Sequence is not everything

Nature Methods volume 6, pages 320–321 (2009)Cite this article

A new algorithm for identifying evolutionary constraint incorporates information on local DNA topology, and leads to the finding that this topology is conserved across species.

Think of the structure of DNA, and what most probably comes to mind is the iconic double helix. Or, if you are a bioinformatician, like Elliott Margulies at the National Human Genome Research Institute, you may be prone to thinking of DNA as a string of characters on a computer screen.

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References

  1. Parker, S.C.J. et al. Local DNA topography correlates with functional noncoding regions of the human genome. Science advance online publication (12 March 2009).

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  1. Natalie de Souza
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de Souza, N. Sequence is not everything. Nat Methods 6, 320–321 (2009). https://doi.org/10.1038/nmeth0509-320b

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  • DOI: https://doi.org/10.1038/nmeth0509-320b

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