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Faster is better: improving the sensitivity of solid-state NMR

Nature Methods volume 6, pages 197–198 (2009)Cite this article

A method to improve the sensitivity of solid-state nuclear magnetic resonance spectroscopy promises to extend this technology to larger and more biologically interesting systems than previously feasible.

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Figure 1: The 13C spectrum of uniformly 13C-labeled ubiquitin in microcrystals collected using the PACC approach is nearly identical to the 13C spectrum collected using the traditional solid-state NMR spectroscopy approach, but in one-quarter of the time.

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Authors and Affiliations

  1. Stanley J. Opella is in the Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA. sopella@ucsd.edu,

    Stanley J Opella

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  1. Stanley J Opella
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Competing interests

S.J.O. is a principal of Membrane Receptor Technologies, a company that applies solid-state NMR to drug receptors.

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Opella, S. Faster is better: improving the sensitivity of solid-state NMR. Nat Methods 6, 197–198 (2009). https://doi.org/10.1038/nmeth0309-197

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