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Longer is better

Nature Methods volume 2, pages 156–157 (2005)Cite this article

Abstract

The efficiency of RNA interference can be vastly improved by using longer RNA oligonucleotides, 27- to 29-mers instead of the conventional 21-mers.

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References

  1. Kim, D.H. et al. Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat. Biotechnol. 23, 222–226 (2005).

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  2. Siolas, D. et al. Synthetic shRNAs as potent RNAi triggers. Nat. Biotechnol. 23, 227–231 (2005).

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Authors
  1. Nicole Rusk
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Rusk, N. Longer is better. Nat Methods 2, 156–157 (2005). https://doi.org/10.1038/nmeth0305-156b

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  • DOI: https://doi.org/10.1038/nmeth0305-156b

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