Correspondence

Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo

  • Subscribe to Nature Methods for full access:

    $59

    Subscribe

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    et al. Nat. Methods 14, 547–548 (2017).

  2. 2.

    & Annu. Rev. Biophys. 46, 505–529 (2017).

  3. 3.

    et al. Nat. Biotech. 31, 681–683 (2013).

  4. 4.

    et al. PLoS ONE 8, e68708 (2013).

  5. 5.

    et al. Genome Res. 25, 1125–1134 (2015).

  6. 6.

    et al. Genome Med. 8, 16 (2016).

  7. 7.

    et al. Nat. Methods 12, 479 (2015).

  8. 8.

    et al. Sci. Rep. 6, 34703 (2016).

  9. 9.

    Anonymous. Nat. Methods 14, 541 (2017).

Download references

Acknowledgements

The authors are funded to produce mouse models using Cas9 as part of the International Mouse Phenotyping Consortium from Genome Canada and Ontario Genomics OGI-051 (L.M.J.N.), the National Human Genome Research Institute, the NIH Common Fund, through the Office of Strategic Coordination/Office of the NIH Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institute on Deafness and Other Communication Disorders, National Institute of Environmental Health Sciences, National Institute of Drug Abuse and the Office of Research on Women's Health awards UM1HG006348 (J.D.H., J.R.S., L.T., S.D.M.B.), UM1OD023321 (L.M.J.N., K.C.L.) and UM1OD023222 (S.D.M.) and MRC IMPC Strategic Award 53658 (L.T., S.D.M.B.).

Author information

Affiliations

  1. Lauryl M.J. Nutter, Steve D.M. Brown, and Mark Moore are, respectively, chairs of the IMPC Cas9 Working Group and the IMPC Steering Committee and executive director of the IMPC (www.mousephenotype.org).

    • Lauryl M J Nutter
    • , Steve D M Brown
    •  & Mark Moore
  2. Lauryl M.J. Nutter is at The Centre for Phenogenomics, The Hospital for Sick Children, Toronto, Canada.

    • Lauryl M J Nutter
  3. Jason D. Heaney and John R. Seavitt are at the Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.

    • Jason D Heaney
    •  & John R Seavitt
  4. K.C. Kent Lloyd is at the Mouse Biology Program, University of California, Davis, Davis, California, USA.

    • K C Kent Lloyd
  5. Stephen A. Murray is at The Jackson Laboratory, Bar Harbor, Maine, USA.

    • Stephen A Murray
  6. William C. Skarnes is at The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.

    • William C Skarnes
  7. Lydia Teboul is at the Mary Lyon Centre and Steve D.M. Brown is at the Mammalian Genetics Unit, Medical Research Center (MRC) Harwell Institute, Harwell, UK.

    • Lydia Teboul
  8. Steve D.M. Brown is at the Mammalian Genetics Unit, Medical Research Center (MRC) Harwell Institute, Harwell, UK.

    • Steve D M Brown

Authors

  1. Search for Lauryl M J Nutter in:

  2. Search for Jason D Heaney in:

  3. Search for K C Kent Lloyd in:

  4. Search for Stephen A Murray in:

  5. Search for John R Seavitt in:

  6. Search for William C Skarnes in:

  7. Search for Lydia Teboul in:

  8. Search for Steve D M Brown in:

  9. Search for Mark Moore in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Lauryl M J Nutter.