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A revolution coming to a classic model organism

Nature Methods volume 10, pages 303–306 (2013)Cite this article

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Classic gene targeting and gene replacement can now be achieved in zebrafish after cleaving the genome with engineered nucleases in the presence of donor DNA. This simple-to-implement method enables new classes of biological study in this important model organism.

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Figure 1: Engineering the zebrafish genome with TALENs.

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  1. David Jonah Grunwald is in the Department of Human Genetics, University of Utah, Salt Lake City, Utah, USA.,

    David Jonah Grunwald

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  1. David Jonah Grunwald
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Correspondence to David Jonah Grunwald.

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The author declares no competing financial interests.

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Grunwald, D. A revolution coming to a classic model organism. Nat Methods 10, 303–306 (2013). https://doi.org/10.1038/nmeth.2415

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