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A ligand's-eye view of protein similarity

Classification of proteins by ligand binding similarity offers an alternative approach to evolutionary methods for organizing and understanding biology, allowing new insights into protein function and physiological signal transduction.

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Figure 1: Representation of protein space as planes containing islands of sequence-related proteins; families showing slower ligand-induced responses are toward the front of the plane.

Marina Corral

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Correspondence to John P Overington.

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van Westen, G., Overington, J. A ligand's-eye view of protein similarity. Nat Methods 10, 116–117 (2013). https://doi.org/10.1038/nmeth.2339

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