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Spinning up mass spectrometry for whole protein complexes

Nature Methods volume 9, pages 10651066 (2012) | Download Citation

Researchers adapt a popular Orbitrap-based mass spectrometer to detect and analyze large, intact protein complexes, accelerating a new frontier in structural biology.

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Author information

Affiliations

  1. Philip D. Compton is in the Department of Chemistry, Northwestern University, Evanston, Illinois, USA.

    • Philip D Compton
  2. Neil L. Kelleher is in the Departments of Chemistry and Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.

    • Neil L Kelleher

Authors

  1. Search for Philip D Compton in:

  2. Search for Neil L Kelleher in:

Competing interests

N.L.K. holds a sponsored research agreement with Thermo Scientific, the company that produces the Exactive Plus. P.D.C. executes the agreement.

Corresponding author

Correspondence to Neil L Kelleher.

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DOI

https://doi.org/10.1038/nmeth.2216

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