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Spinning up mass spectrometry for whole protein complexes

Nature Methods volume 9, pages 10651066 (2012) | Download Citation

Researchers adapt a popular Orbitrap-based mass spectrometer to detect and analyze large, intact protein complexes, accelerating a new frontier in structural biology.

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  1. 1.

    , , , & Nat. Methods 9, 1084–1086 (2012).

  2. 2.

    Am. Biotechnol. Lab. 11, 32–34 (1993).

  3. 3.

    , , & Ther. Drug Monit. 15, 563–569 (1993).

  4. 4.

    et al. Science 334, 380–385 (2011).

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Author information


  1. Philip D. Compton is in the Department of Chemistry, Northwestern University, Evanston, Illinois, USA.

    • Philip D Compton
  2. Neil L. Kelleher is in the Departments of Chemistry and Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.

    • Neil L Kelleher


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Competing interests

N.L.K. holds a sponsored research agreement with Thermo Scientific, the company that produces the Exactive Plus. P.D.C. executes the agreement.

Corresponding author

Correspondence to Neil L Kelleher.

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