News & Views | Published:

Organoids: Modelling polycystic kidney disease

Nature Materials volume 16, pages 10581059 (2017) | Download Citation

Cysts were generated from organoids in vitro and the removal of adherent cues was shown to play a key role in polycystic kidney disease progression. These cysts resembled those of diseased tissue phenotypically and were capable of remodelling their microenvironment.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from $8.99

All prices are NET prices.

References

  1. 1.

    et al. Nat. Mater. 16, 1112–1119 (2017).

  2. 2.

    , , & Lancet 385, 1993–2002 (2015).

  3. 3.

    & J. Am. Soc. Nephrol. 18, 1374–1380 (2007).

  4. 4.

    & Nat. Rev. Nephrol. 10, 587–601 (2014).

  5. 5.

    et al. Kidney Int. 47, 861–868 (1995).

  6. 6.

    et al. Nat. Cell Biol. 3, 831–838 (2001).

Download references

Author information

Affiliations

  1. Paola Romagnani is in the Department of Biomedical and Experimental Sciences 'Mario Serio', and at the Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), and the Pediatric Nephrology Unit, Meyer Children's Hospital, University of Florence, 50139 Florence, Italy

    • Paola Romagnani

Authors

  1. Search for Paola Romagnani in:

Corresponding author

Correspondence to Paola Romagnani.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nmat5013