Stem cell reprogramming

A 3D boost

Biophysical factors in an optimized three-dimensional microenvironment enhance the reprogramming efficiency of human somatic cells into pluripotent stem cells when compared to traditional cell-culture substrates.

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Figure 1: 3D iPSC generation.
Figure 2: High-throughput screening approach to optimize iPSC reprogramming efficiency.

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Correspondence to Oscar J. Abilez or Joseph C. Wu.

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Abilez, O., Wu, J. A 3D boost. Nature Mater 15, 259–261 (2016). https://doi.org/10.1038/nmat4583

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