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Supramolecular materials

Longer and safer gastric residence

A supramolecular polymer that is stable in the acidic environment of the stomach but dissolves in the neutral-pH environment of the intestines prolongs the safe retention of gastric devices.

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Figure 1: Morphology of the human gastrointestinal tract and pH values in different parts of the tract.
Figure 2: A prototype gastric-retentive device.

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Correspondence to Vitaliy V. Khutoryanskiy.

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Khutoryanskiy, V. Longer and safer gastric residence. Nature Mater 14, 963–964 (2015). https://doi.org/10.1038/nmat4432

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