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Stem cell differentiation

Post-degradation forces kick in

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Stem cells alter their morphology and differentiate to particular lineages in response to biophysical cues from the surrounding matrix. When the matrix is degradable, however, cell fate is morphology-independent and is directed by the traction forces that the cells actively apply after they have degraded the matrix.

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Figure 1: Degradable hydrogels stimulate osteogenic differentiation of mesenchymal stem cells2.
Figure 2: Cell-mediated reorganization of matrix-bound ligands.

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Correspondence to Adam J. Engler.

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Vincent, L., Engler, A. Post-degradation forces kick in. Nature Mater 12, 384–386 (2013). https://doi.org/10.1038/nmat3636

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