At present, when intervertebral discs fail, the only existing treatments are fusion of neighbouring vertebrae or polymer and metal implants. A tissue-engineering approach using an electrospun-fibre laminated scaffold could provide functional equivalence with native tissues in both construction form and strength.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats
Arthritis Research & Therapy Open Access 28 May 2021
-
The effect of the fibre orientation of electrospun scaffolds on the matrix production of rabbit annulus fibrosus-derived stem cells
Bone Research Open Access 09 June 2015
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hukins, D. W. Nature Mater. 4, 881–882 (2005).
Nerurkar, N. L. et al. Nature Mater. 8, 986–992 (2009).
Iatridis, J. C., Michalek, A. J., Purmessur, D. & Korecki, C. L. Cell. Mol. Bioeng. 2, 437–447 (2009).
Ruan, D. et al. Lancet 369, 993–999 (2007).
Kandel, R., Roberts, S. & Urban, J. P. Eur. Spine J. 17, 480–491 (2008).
Sobajima, S. et al. Spine J. 8, 888–896 (2008).
Michalek, A. J., Buckley, M. R., Bonassar, L. J., Cohen, I. & Iatridis, J. C. J. Biomech. 42, 2279–2285 (2009).
Setton, L. A. & Chen, J. J. Bone Joint Surg. Am. 88, 52–57 (2006).
Sakai, D., Nakai, T., Mochida, J., Alini, M. & Grad, S. Spine 34, 1448–1456 (2009).
Lotz, J. C. Spine 29, 2742–2750 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Iatridis, J. Function follows form. Nature Mater 8, 923–924 (2009). https://doi.org/10.1038/nmat2577
Issue Date:
DOI: https://doi.org/10.1038/nmat2577
This article is cited by
-
Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats
Arthritis Research & Therapy (2021)
-
The effect of the fibre orientation of electrospun scaffolds on the matrix production of rabbit annulus fibrosus-derived stem cells
Bone Research (2015)