Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Biocide squirting from an elastomeric tri-layer film

Abstract

Protective layers typically act in a passive way by simply separating two sides. Protection is only efficient as long as the layers are intact. If a high level of protection has to be achieved by thin layers, complementary measures need to be in place to ensure safety, even after breakage of the layer—an important issue in medical applications1,2,3,4,5,6,7,8,9. Here, we present a novel approach for integrating a biocide liquid into a protective film (about 300–500 μm thick), which guarantees that a sufficient amount of biocide is rapidly released when the film is punctured. The film is composed of a middle layer, containing the liquid in droplet-like compartments, sandwiched between two elastomeric boundary layers. When the film is punctured, the liquid squirts out of the middle layer. A theoretical model was used to determine the size and density of droplets that are necessary to ensure a sufficient quantity of biocide is expelled from an adequately elastic matrix to provide protection at the site of damage. We demonstrate the utility of this approach for the fabrication of surgical gloves.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Key principle of the active tri-layer film.
Figure 2: Experimental realization of the active tri-layer film.
Figure 3: Mechanical properties at rupture of a tri-layer system as a function of the content of the disinfecting agent.
Figure 4: Volume of expelled active liquid (VAL) after puncture of film.

Similar content being viewed by others

References

  1. Farrel, B.D., Dessourd, D.E. & Mitter, C. Escalation of plant defenses: do latex and resin canals spur plant diversification Am. Nat. 138, 881–900 (1991).

    Article  Google Scholar 

  2. Gennaro, A.R. (ed.) Remington: The Science and Practice of Pharmacy (Lippincott, Williams & Wilkins, Maryland, USA, 2000).

    Google Scholar 

  3. F1671-97b: Standard test method for resistance of materials used in protective clothing to penetration by blood borne pathogens using Phi-X174 bacteriophage penetration as a test system. Book of Standards vol. 11.03 (American Society for Testing and Materials International, 1997).

  4. Tokars, J.I. et al. Skin and mucous membrane contact with blood during surgical procedures: risk and prevention. Infect. Control Hosp. Epidemiol. 16, 703–711 (1995).

    Article  CAS  Google Scholar 

  5. McLeod, G.G. Needlestick injuries at operations for trauma: are surgical gloves an effective barrier? J. Bone Joint Surg. 71, 489–491 (1989).

    Article  CAS  Google Scholar 

  6. Data reports from the Exposure Prevention Information Network. (University of Virginia International Health Care Worker Safety Center, 2001) http://www.med.virginia.edu/medcntr/centers/epinet

  7. Case control study of HIV seroconversion in health-care workers after percutaneous exposure to HIV infected blood France, United Kingdom and United States. Centers for Disease Control and Prevention. Mortality and Morbidity Weekly Report 44, 929–933 (1995).

  8. Bell, D.M. Occupational risk of human immunodeficiency virus infection in healthcare workers: an overview. Am. J. Med. 102, 9–15 (1997).

    Article  CAS  Google Scholar 

  9. Suzuki, K. et al. Confirmation of HCV transmission through needlestick accident by molecular evolutionary analysis. J. Infect. Dis. 170, 1575–1580 (1994).

    Article  CAS  Google Scholar 

  10. Agusti, M. et al. Histological and physiological characterization of rind breakdown of 'Navelate' sweet orange. Ann. Bot. 88, 415–422 (2001).

    Article  Google Scholar 

  11. Riess, G., Cheymol, A., Hoerner, P. & Krikorian, R. Non-aqueous emulsions stabilized by block copolymers: application to liquid disinfectant-filled elastomeric films. Adv. Colloid Interface Sci. published online 2 December 2003 (doi:10.1016/j.cis.2003.10.019).

  12. Krikorian, R. Contribution à l'Étude de la Cristallisation en Solution de Copolymères à Blocs. Application à la Stabilisation d'Émulsions Thesis, Univ. Mulhouse (2001).

    Google Scholar 

  13. Hoerner, P., Riess, G., Rittig, F. & Fleischer, G. Emulsification of poly(ethylene glycol) in thermoplastic elastomers by using polybutadiene-block-poly(ethylene oxide) diblock copolymers as stabilisers. Determination of the liquid phase mobility by pulsed field gradient NMR. Chem. Phys. 199, 343–352 (1998).

    CAS  Google Scholar 

  14. Studer, P. Les Copolymers Diblocs Semi-crystallins Thesis, Univ. Haute Alsace, Mulhouse (1998).

    Google Scholar 

  15. Thieme, J., Abend, S. & Lagaly, G. Aggregation in Pickering solution. Colloid Polym. Sci. 277, 257–260 (1999).

    Article  CAS  Google Scholar 

  16. Aveyard, R., Binks, B.P. & Clint, J.H. Emulsions stabilized solely by colloidal particles. Adv. Colloid Interface Sci. 100–102, 503–546 (2003).

    Article  Google Scholar 

  17. Gibson, L.J. & Ashby, M.F. Cellular Solids, Structure and Properties 2nd edn (Cambridge Univ. Press, 1997).

    Book  Google Scholar 

  18. Mc Cormack, T.M., Miller, R., Kesler, O. & Gibson, L.J. Failure of sandwich beam with metallic foam cores. Intl J. Solids Struct. 38, 4901–4920 (2001).

    Article  Google Scholar 

  19. Warner, M., Thiel, B.L. & Donald, A.M. The elasticity and failure of fluid filled cellular solids: theory and experiment. Proc. Natl Acad. Sci. USA 97, 1370–1375 (2000).

    Article  CAS  Google Scholar 

  20. Van den Sanden, M.C.M., Meijer, H.E.H. & Lemstra, P.J. Polymer Deformation and toughness of polymeric systems: 1. The concept of a critical thickness. Polymer 34, 2148–2154 (1993).

    Article  Google Scholar 

  21. Deegan, R.D., Petersan, P.J., Marder, M. & Swinney, H.L. Oscillating fracture path in rubber. Phys. Rev. Lett. 88, 014304 (2001).

    Article  Google Scholar 

  22. Bricout, F. et al. Virus-inhibiting surgical gloves to reduce the risk of infection by enveloped viruses. J. Med. Virol. 69, 538–545 (2003).

    Article  Google Scholar 

Download references

Acknowledgements

We gratefully acknowledge the technical assistance of Raffi Krikorian, Mapa Research Center, Liancourt, France. This work has been partially supported by European Commission (Grant: BMH4-97-2325).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Philippe Sonntag.

Ethics declarations

Competing interests

Patent filed

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sonntag, P., Hoerner, P., Cheymol, A. et al. Biocide squirting from an elastomeric tri-layer film. Nature Mater 3, 311–315 (2004). https://doi.org/10.1038/nmat1113

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmat1113

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing