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The genome's best friend

Nature Genetics volume 31, pages 331–332 (2002)Cite this article

DNA replication through mononucleotide runs is frequently associated with slippage of DNA polymerase, leading to the insertion or deletion of a small number of base pairs. A new study shows that, in the absence of DOG-1, a putative helicase, long poly(dG/C) runs are associated with deletions that extend into flanking DNA sequences. This mutational signature may be related to the ability of poly(dG) to form secondary structures such as G-quadruplex DNA, and may contribute to the genomic instability of tumor cells.

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Figure 1: Mutations in dog-1 cause a mutator phenotype, which generates deletions near G-rich sequences.
Figure 2: A model for DOG-1 action.

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  1. Department of Biology, Emory University, Atlanta, 30322, Georgia, USA

    Sue Jinks-Robertson

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  1. Sue Jinks-Robertson
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Jinks-Robertson, S. The genome's best friend. Nat Genet 31, 331–332 (2002). https://doi.org/10.1038/ng936

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