Decades after the first report of a complement-activating factor in the serum of some people with chronic glomerulonephritis, its causal role in the disease is still debated. In a new study, mice engineered to lack a regulatory protein, factor H, uniformly develop glomerulonephritis, and have ongoing consumption of serum complement similar to that seen in humans.
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Welch, T. Complement in glomerulonephritis. Nat Genet 31, 333–334 (2002). https://doi.org/10.1038/ng933
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DOI: https://doi.org/10.1038/ng933
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