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Identification of SLC39A4, a gene involved in acrodermatitis enteropathica

Nature Genetics volume 31, pages 239240 (2002) | Download Citation

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Abstract

We have characterized the human gene SLC39A4, which encodes a protein with features characteristic of a ZIP zinc transporter. The chromosomal location and expression of SLC39A4, together with mutational analysis of eight families affected with acrodermatitis enteropathica, suggest that SLC39A4 is centrally involved in the pathogenesis of this condition.

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Acknowledgements

This study was supported by the University Hospital of Nantes (Direction Régionale de la Recherche Clinique). S. Küry is recipient of a grant from the Association Anne de Bretagne Génétique. We are grateful to the members of the families with acrodermatitis enteropathica who collaborated on this work and to R. Breathnach for his help in the writing of this article.

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Affiliations

  1. Laboratoire d'Etude du Polymorphisme de l'ADN, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France.

    • Sébastien Küry
    • , Stéphane Bézieau
    • , Stéphanie Giraudet
    •  & Jean-Paul Moisan
  2. Service de Dermatologie, Hôtel-Dieu, Centre Hospitalier Universitaire, 44093 Nantes Cedex, France.

    • Brigitte Dréno
  3. Service de Dermatologie, Hôpital Charles Nicolle, Tunis, Tunisia.

    • Monia Kharfi
    •  & Ridha Kamoun

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Sébastien Küry.

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DOI

https://doi.org/10.1038/ng913

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