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Early death of mice cloned from somatic cells

Nature Genetics volume 30, pages 253254 (2002) | Download Citation

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Abstract

Here we report that the lifespan of mice cloned from somatic cells is significantly shorter than that of genotype- and sex-matched controls, most likely due to severe pneumonia and hepatic failure. This finding demonstrates the possibility of long-term deleterious effects of somatic-cell cloning, even after normal birth.

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Acknowledgements

This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology; the Ministry of Health, Labor and Welfare; and the Human Science Foundation of Japan.

Author information

Author notes

    • Kentaro Tanemura

    Present address: Laboratory for Alzheimer's Disease, Brain Science Institute, RIKEN, Saitama, Japan.

    • Narumi Ogonuki
    • , Kimiko Inoue
    •  & Yoshie Yamamoto

    These authors contributed equally to this work.

Affiliations

  1. Department of Veterinary Science, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.

    • Narumi Ogonuki
    • , Kimiko Inoue
    • , Yoshie Yamamoto
    • , Yoko Noguchi
    • , Kentaro Tanemura
    • , Osamu Suzuki
    •  & Atsuo Ogura
  2. Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

    • Hiroyuki Nakayama
    •  & Kunio Doi
  3. Graduate School of Agricultural Science, Faculty of Agriculture, Tohoku University, Sendai, Japan.

    • Yukiko Ohtomo
    • , Michiko Satoh
    •  & Akira Nishida

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Atsuo Ogura.

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DOI

https://doi.org/10.1038/ng841

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