Brief Communication | Published:

A common genetic risk factor for colorectal and prostate cancer

Nature Genetics volume 39, pages 954956 (2007) | Download Citation

Abstract

Variants on chromosome 8q24 contribute risk for prostate cancer; here, we tested whether they also modulate risk for colorectal cancer. We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer (odds ratio = 1.22; P = 4.4 × 10−6) and that the apportionment of risk among the variants differs significantly between the two cancers. Comprehensive testing in the region uncovered variants capturing significant additional risk. Our results show that variants at 8q24 have different effects on cancer development that depend on the tissue type.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Proc. Natl. Acad. Sci. USA 103, 14068–14073 (2006).

  2. 2.

    et al. Nat. Genet. 39, 638–644 (2007).

  3. 3.

    et al. Nat. Genet. 38, 652–658 (2006).

  4. 4.

    et al. Nat. Genet. 39, 631–637 (2007).

  5. 5.

    et al. Nat. Genet. 39, 645–649 (2007).

  6. 6.

    et al. Cancer Res. 55, 342–347 (1995).

  7. 7.

    et al. Prostate 67, 692–700 (2007).

  8. 8.

    et al. Genes Chromosom. Cancer 15, 234–245 (1996).

  9. 9.

    et al. Cancer Res. 64, 4817–4825 (2004).

  10. 10.

    et al. Nature 447, 661–678 (2007).

  11. 11.

    et al. Nature 344, 435–439 (1990).

  12. 12.

    et al. Cell 95, 379–391 (1998).

  13. 13.

    et al. Biochem. Biophys. Res. Commun. 337, 1047–1051 (2005).

Download references

Acknowledgements

We thank the men and women who participated in these studies. We are grateful to L. Pooler, D. Wong, J. Neubauer, C. Schirmer and A. Waliszewska for assistance with genotyping, and to D. Altshuler, B. Berman, S. Greenway, M. Freedman, S. Myers, N. Patterson, J. Seidman for discussions and comments on the manuscript. The collection and genotyping of samples from the Multiethnic Cohort Study was supported by US National Institutes of Health (NIH) grants CA63464 and CA54281. The Hawaii-based case-control study was supported by NIH grants CA60987 and CA72520 from the National Cancer Institute, United States Department of Health and Human Services. The Los Angeles-based case-control study was supported by grant P01 CA17054 from the National Cancer Institute. D.R. is supported by a Burroughs-Wellcome Center Development Award in the Biomedical Sciences.

Author information

Affiliations

  1. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.

    • Christopher A Haiman
    • , Daniel O Stram
    • , Xin Sheng
    • , Anna H Wu
    •  & Brian E Henderson
  2. Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA.

    • Loïc Le Marchand
    • , Jennifer Yamamato
    •  & Laurence N Kolonel
  3. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.

    • David Reich
  4. Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

    • David Reich

Authors

  1. Search for Christopher A Haiman in:

  2. Search for Loïc Le Marchand in:

  3. Search for Jennifer Yamamato in:

  4. Search for Daniel O Stram in:

  5. Search for Xin Sheng in:

  6. Search for Laurence N Kolonel in:

  7. Search for Anna H Wu in:

  8. Search for David Reich in:

  9. Search for Brian E Henderson in:

Contributions

The studies were initiated by B.E.H., L.N.K., L.L.M. and A.H.W. The genotyping was performed under the direction of C.A.H., L.L.M. and D.R. Covariate datasets were generated by J.Y. under the direction of L.L.M. The statistical analysis was performed by C.A.H. with the assistance of D.R., X.S. and D.O.S. The manuscript was written by C.A.H. with the assistance of D.R. and all co-authors.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Christopher A Haiman.

Supplementary information

PDF files

  1. 1.

    Supplementary Text and Figures

    Supplementary Figures 1–2, Supplementary Tables 1–5, Supplementary Methods

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/ng2098

Further reading