Lipoprotein lipase, the enzyme that hydrolyzes fatty acids from triglycerides carried by circulating lipoproteins, resides on the surface of the capillary endothelium. Analysis of a hypertriglyceridemic mutant mouse has now identified a protein, LMF1, that is critical for the transport of active lipoprotein lipase through the secretory pathway.
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Attie, A. High-maintenance proteins and hypertriglyceridemia. Nat Genet 39, 1424–1425 (2007). https://doi.org/10.1038/ng1207-1424
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DOI: https://doi.org/10.1038/ng1207-1424
