Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Sudden and unexpected

Infections have been implicated in sudden and unexpected deaths, but evidence of causality and insights into underlying mechanisms are lacking. Now, a new study in mice identifies a homeostatic mechanism that seems critical for stabilizing the host response after microbial infection.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Comparison of physiological responses to endotoxemia in wild-type (right) and Kir6.1-deficient mice (left).

References

  1. Croker, B. et al. Nat. Genet. 39, 1453–1460 (2007).

    Article  CAS  Google Scholar 

  2. Aguilar-Bryan, L. & Bryan, J. Endocr. Rev. 20, 101–135 (1999).

    CAS  PubMed  Google Scholar 

  3. Miki, T. et al. Nat. Med. 8, 466–472 (2002).

    Article  CAS  Google Scholar 

  4. Chutkow, W.A. et al. J. Clin. Invest. 110, 203–208 (2002).

    Article  CAS  Google Scholar 

  5. Minami, K. et al. Diabetes 53, S176–S180 (2004).

    Article  CAS  Google Scholar 

  6. Kane, G.C. et al. FASEB J. 20, 2271–2280 (2006).

    Article  CAS  Google Scholar 

  7. Cook, M.C., Vinuesa, C.G. & Goodnow, C.C. Curr. Opin. Immunol. 18, 627–633 (2006).

    Article  CAS  Google Scholar 

  8. Beutler, B. et al. Nat. Rev. Immunol. 7, 753–766 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Balling, R. Sudden and unexpected. Nat Genet 39, 1422–1423 (2007). https://doi.org/10.1038/ng1207-1422

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1207-1422

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing