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Making the commitment to meiosis

Analysis of the phenotype of mouse germ cells deficient for the retinoic acid–responsive gene Stra8 provides insight into the timing of the commitment to enter meiosis in mammals. The observations suggest that, as in other eukaryotes, this commitment precedes (or coincides with) the commitment to premeiotic DNA replication.

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Figure 1: This flowchart depicts the steps of mammalian gametogenesis with an emphasis on the progression through mitosis and meiosis.

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Wolgemuth, D. Making the commitment to meiosis. Nat Genet 38, 1362–1363 (2006). https://doi.org/10.1038/ng1206-1362

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