A new study identifies a cell-autonomous two-hour clock in diverse types of mammalian cells in culture. The two-hour oscillations depend on negative feedback of a gene product, Hes1, on transcription of its own gene—a regulatory mechanism that is identical to the circadian clock. Although a similar two-hour clock is required for vertebrate somitogenesis, the physiological role of the two-hour clock in cells remains unclear.
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Nitabach, M., Blau, J. Cellular clockwork. Nat Genet 32, 559–560 (2002). https://doi.org/10.1038/ng1202-559
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DOI: https://doi.org/10.1038/ng1202-559
