Letter | Published:

Quantitative trait loci analysis affecting contextual conditioning in mice

Nature Genetics volume 17, pages 335337 (1997) | Download Citation

Subjects

Abstract

In an extensive backcross of mice between C3H/HeJ (C3H) and C57BL/6J (B6), we sought to map genes that influence learning and memory as measured by performance in a contextual fear-conditioning paradigm. Our results indicate that there are several genetic regions that have a strong influence on performance in this paradigm. The strongest influences map to the proximal and distal ends of chromosome 1 (lod scores of 5.14 and 4.76, respectively). Other chromosomal regions (chromosomes 3, 7, 8, 9 and 18) were also identified as candidates for regions containing genes influencing contextual fear conditioning, with lod scores ranging from 1.8 to 2.7.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell. 79, 59–68 (1994).

  2. 2.

    et al. Alpha calcium/calmodulin kinase II mutant mice: deficient long-term potentiation and impaired spatial learning. Cold Spring Harbor Symp. Quant. Biol. 57, 527–539 (1992).

  3. 3.

    et al. Impaired learning in mice with abnormal short-lived plasticity. Curr. Biol. 6, 1509–1518 (1996).

  4. 4.

    et al. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell. 79, 365–375 (1994).

  5. 5.

    & Modality-specific retrograde amnesia of fear. Science. 256, 675–677 (1992).

  6. 6.

    & Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106, 274–285 (1992).

  7. 7.

    & Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241–247 (1995).

  8. 8.

    & Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics. 121, 185–199 (1989).

  9. 9.

    et al. A simple genetic basis for a complex psychological trait in laboratorymice. Science. 269, 1432–1435 (1995).

  10. 10.

    , , , & , Quantitative trait loci associated with the behavioral response of BXD recombinant inbred mice to restraint stress: a preliminary communication. Behav. Genet. 25, 489–495 (1995).

  11. 11.

    et al. Quantitative trait loci analysis of contextual fear conditioning in mice. Nature Genet. 17, 331–334 (1997).

  12. 12.

    , , & DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning. Behav.Neurosci. 108, 810–817 (1994).

  13. 13.

    et al. Resolution of quantitative traits into Mendelian factors using a complete linkage map of restriction fragment length polymorphisms.. Nature. 335, 721–726 (1988).

  14. 14.

    et al. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293 (1991).

  15. 15.

    et al. A genetic map of the mouse suitable for typing intraspecific crosses. Genetics. 131, 423–447 (1992).

  16. 16.

    et al. A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nature Genet. 7, 220–245 (1994).

Download references

Author information

Affiliations

  1. Departments of Psychology and Biomedical Sciences, University at Albany, State University of New York, Albany, New York 12222, USA.

    • Barbara Caldarone
    • , Carlos Saavedra
    • , Kathleen Tartaglia
    • , Bruce C Dudek
    •  & Lorraine Flaherty
  2. Molecular Genetics Program, Wadsworth Center, Albany, New York, 12201-2002 USA.

    • Barbara Caldarone
    • , Carlos Saavedra
    • , Kathleen Tartaglia
    •  & Lorraine Flaherty
  3. The Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA.

    • Jeanne M Wehner
    •  & Lorraine Flaherty
  4. e-mail: flaherty@wadsworth.org

    • Lorraine Flaherty

Authors

  1. Search for Barbara Caldarone in:

  2. Search for Carlos Saavedra in:

  3. Search for Kathleen Tartaglia in:

  4. Search for Jeanne M Wehner in:

  5. Search for Bruce C Dudek in:

  6. Search for Lorraine Flaherty in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/ng1197-335