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PBDX is the XG blood group gene

Nature Genetics volume 8, pages 285–290 (1994)Cite this article

Abstract

We have identified the Xga antigen, encoded by the XG blood group gene, by employing rabbit polyclonal and mouse monoclonal antibodies raised against a peptide derived from the N-terminal domain of a candidate gene, referred to earlier as PBDX. In indirect haemagglutination assays, these anti-peptide antibodies react with Xg(a+) but not Xg(a−) erythrocytes. In antibody-specific immobilization of antigen (ASIA) and immunoblot assays, the anti-peptide antibodies react with the same molecule as does human anti-Xga. Therefore, by its identity with PBDX, Xga is identified as a cell-surface protein that is 48% homologous to CD99 (previously designated the 12E7 antigen), the product of MIC2 which is tightly linked to XG. PBDX is renamed here XG.

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Authors and Affiliations

  1. New York Blood Center, 310 East 67th Street, New York, New York, 10021, USA

    Nathan A. Ellis, Marion Reid, Tian Z. Ye & James German

  2. MRC Blood Group Unit, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK

    Patricia Tippett & Alison Petty

  3. Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK

    Polly A. Weller

  4. Department of Biochemistry, and Science and Engineering Research Council Molecular Recognition Center, School of Medical Sciences, University of Bristol, University Walk, Bristol, 1TD, UK

    Peter N. Goodfellow, Stephen Thomas & George Banting

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Ellis, N., Tippett, P., Petty, A. et al. PBDX is the XG blood group gene. Nat Genet 8, 285–290 (1994). https://doi.org/10.1038/ng1194-285

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