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Different noses for different people

Nature Genetics volume 34, pages 143144 (2003) | Download Citation

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Abstract

Of more than 1,000 human olfactory receptor genes, more than half seem to be pseudogenes. We investigated whether the most recent of these disruptions might still segregate with the intact form by genotyping 51 candidate genes in 189 ethnically diverse humans. The results show an unprecedented prevalence of segregating pseudogenes, identifying one of the most pronounced cases of functional population diversity in the human genome.

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Acknowledgements

We thank M. Przeworski for helpful discussions. D.L. holds the Ralph and Lois Silver Chair in Human Genomics. This work was supported by the Crown Human Genome Center at the Weizmann Institute of Science and by an Israel Ministry of Science grant to the National Laboratory for Genome Infrastructure.

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Affiliations

  1. Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel.

    • Idan Menashe
    • , Orna Man
    • , Doron Lancet
    •  & Yoav Gilad

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Doron Lancet.

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DOI

https://doi.org/10.1038/ng1160

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