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Lethal combinations

Synthetic lethality occurs when two otherwise nonlethal mutations together result in an inviable cell. A new study describes a rapid approach to identify synthetic lethal mutations in yeast.

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Figure 1: Comparison of genome-wide synthetic lethal screening methods.

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Tucker, C., Fields, S. Lethal combinations. Nat Genet 35, 204–205 (2003). https://doi.org/10.1038/ng1103-204

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