Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Uniting the paths to gene silencing

Nature Genetics volume 32, pages 340–341 (2002)Cite this article

A new study of ribosomal RNA gene silencing in the mouse provides clues as to how repressive chromatin states become established. At center stage is a chromatin remodeling complex that recruits DNA methyltransferase and histone deacetylase activities to the gene promoter, initiating a process that includes de novo DNA methylation, methylation of histone H3 on Lys9 and heterochromatin protein binding.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Richards, E.J. & Elgin, S.C. Cell 108, 489–500 (2002).

    Article  CAS  Google Scholar 

  2. Tamaru, H. & Selker, E.U. Nature 414, 277–283 (2001).

    Article  CAS  Google Scholar 

  3. Santoro, R., Li, J. & Grummt, I. Nature Genet. 32 (2002); advance online publication, 7 October 2000 (doi: 10.1038/ng1010).

  4. McStay, B. & Reeder, R.H. Genes Dev. 4, 1240–1251 (1990).

    Article  CAS  Google Scholar 

  5. Langst, G., Blank, T.A., Becker, P.B. & Grummt, I. EMBO J. 16, 760–768 (1997).

    Article  CAS  Google Scholar 

  6. Langst, G., Becker, P.B. & Grummt, I. EMBO J. 17, 3135–3145 (1998).

    Article  CAS  Google Scholar 

  7. Strohner, R. et al. EMBO J. 20, 4892–4900 (2001).

    Article  CAS  Google Scholar 

  8. Zhou, Y., Santoro, R. & Grummt, I. EMBO J. 21, 4632–4640 (2002).

    Article  CAS  Google Scholar 

  9. Burgers, W.A., Fuks, F. & Kouzarides, T. Trends Genet. 18, 275–277 (2002).

    Article  CAS  Google Scholar 

  10. Deplus, R. et al. Nucleic Acids Res. 30, 3831–3838 (2002).

    Article  CAS  Google Scholar 

  11. Di Croce, L. et al. Science 295, 1079–1082 (2002).

    Article  CAS  Google Scholar 

  12. Santoro, R. & Grummt, I. Mol. Cell 8, 719–725 (2001).

    Article  CAS  Google Scholar 

  13. Conconi, A., Widmer, R.M., Koller, T. & Sogo, J.M. Cell 57, 753–761 (1989).

    Article  CAS  Google Scholar 

  14. Pikaard, C.S. Trends Genet. 16, 495–500 (2000).

    Article  CAS  Google Scholar 

  15. Chen, Z.J. & Pikaard, C.S. Genes Dev. 11, 2124–2136 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biology Department, Washington University, 1 Brookings Drive, St. Louis, 63122, Missouri, USA

    Craig S. Pikaard & Richard J. Lawrence

Authors
  1. Craig S. Pikaard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Richard J. Lawrence
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pikaard, C., Lawrence, R. Uniting the paths to gene silencing. Nat Genet 32, 340–341 (2002). https://doi.org/10.1038/ng1008

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1008

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing