Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Casting an eye on the Krebs cycle

A new study identifies recessive, loss-of-function mutations in IDH3B, encoding a subunit of the NAD-specific isocitrate dehydrogenase, in individuals with retinitis pigmentosa. The lack of any obvious clinical signs in other tissues in these individuals forces a reassessment of the physiological role of this enzyme outside of the retina.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: The Krebs cycle.

References

  1. Hartong, D.T. et al. Nat. Genet. 40, 1230–1234 (2008).

    Article  CAS  Google Scholar 

  2. Brière, J.J. et al. Am. J. Physiol. Cell Physiol. 291, 1114–1120 (2006).

    Article  Google Scholar 

  3. Bourgeron, T. et al. J. Clin. Invest. 93, 2514–2518 (1994).

    Article  CAS  Google Scholar 

  4. Bourgeron, T. et al. Nat. Genet. 11, 144–149 (1995).

    Article  CAS  Google Scholar 

  5. Haworth, J.C. et al. Pediatrics 58, 564–572 (1976).

    CAS  PubMed  Google Scholar 

  6. Elpeleg, O. et al. Am. J. Hum. Genet. 76, 1081–1086 (2005).

    Article  CAS  Google Scholar 

  7. Ostergaard, E. et al. Am. J. Hum. Genet. 81, 383–387 (2007).

    Article  CAS  Google Scholar 

  8. Tomlinson, I.P. et al. Nat. Genet. 30, 406–410 (2002).

    Article  CAS  Google Scholar 

  9. Baysal, B.E. et al. Science 287, 848–851 (2000).

    Article  CAS  Google Scholar 

  10. Astuti, D. et al. Am. J. Hum. Genet. 69, 49–54 (2001).

    Article  CAS  Google Scholar 

  11. Niemann, S. & Müller, U. Nat. Genet. 26, 268–270 (2000).

    Article  CAS  Google Scholar 

  12. Pollard, P.J. et al. Hum. Mol. Genet. 14, 2231–2239 (2005).

    Article  CAS  Google Scholar 

  13. Maxwell, P.H. et al. Proc. Natl. Acad. Sci. USA 94, 8104–8109 (1997).

    Article  CAS  Google Scholar 

  14. Gimenez-Roqueplo, A.P. et al. Am. J. Hum. Genet. 69, 1186–1197 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Munnich, A. Casting an eye on the Krebs cycle. Nat Genet 40, 1148–1149 (2008). https://doi.org/10.1038/ng1008-1148

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1008-1148

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing