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(Re)modeling the transcriptional enhancer

Transcriptional cis-regulatory modules have a fundamental role in regulating eukaryotic gene expression. A new study shows how computational modeling can test hypotheses about how regulatory elements function, with results that challenge conventional views of their organization.

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Figure 1: Different arrangements of cis-regulatory modules (CRMs).

References

  1. Banerji, J., Rusconi, S. & Schaffner, W. Cell 27, 299–308 (1981).

    Article  CAS  Google Scholar 

  2. Janssens, H. et al. Nat. Genet. 38, 1159–1165 (2006).

    Article  CAS  Google Scholar 

  3. Reinitz, J., Hou, S. & Sharp, D.H. ComPlexUs 1, 54–64 (2003).

    Article  CAS  Google Scholar 

  4. Kulkarni, M.M. & Arnosti, D.N. Development 130, 6569–6575 (2003).

    Article  CAS  Google Scholar 

  5. Arnosti, D.N., Barolo, S., Levine, M. & Small, S. Development 122, 205–214 (1996).

    CAS  Google Scholar 

  6. Carey, M. Cell 92, 5–8 (1998).

    Article  CAS  Google Scholar 

  7. Erives, A. & Levine, M. Proc. Natl. Acad. Sci. USA 101, 3851–3856 (2004).

    Article  CAS  Google Scholar 

  8. Senger, K. et al. Mol. Cell 13, 19–32 (2004).

    Article  CAS  Google Scholar 

  9. Kulkarni, M.M. & Arnosti, D.N. Mol. Cell. Biol. 25, 3411–3420 (2005).

    Article  CAS  Google Scholar 

  10. Klingler, M., Soong, J., Butler, B. & Gergen, J.P. Dev. Biol. 177, 73–84 (1996).

    Article  CAS  Google Scholar 

  11. Yuh, C.H., Bolouri, H. & Davidson, E.H. Science 279, 1896–1902 (1998).

    Article  CAS  Google Scholar 

  12. Halfon, M.S. et al. Cell 103, 63–74 (2000).

    Article  CAS  Google Scholar 

  13. Hallikas, O. et al. Cell 124, 47–59 (2006).

    Article  CAS  Google Scholar 

  14. Li, H. & Wang, W. Curr. Opin. Genet. Dev. 13, 611–616 (2003).

    Article  CAS  Google Scholar 

Download references

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Halfon, M. (Re)modeling the transcriptional enhancer. Nat Genet 38, 1102–1103 (2006). https://doi.org/10.1038/ng1006-1102

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