Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Lymph makes you fat

A new study of mice lacking Prox1, a gene required for the formation of lymphatic endothelial cells, unveils a link between lymph fluid and fat deposition. These findings bring the lymphatic vascular system into the focus of obesity research.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Defects in lymphatic vasculature promote obesity.

References

  1. 1

    Harvey, N. et al. Nat. Genet. 37, 1072–1081 (2005).

    CAS  Article  PubMed  Google Scholar 

  2. 2

    Asellius, G. in De Lacteibus sive lacteis venis Quarto Vasorum mesaroicum genere novo invente Gasp (Mediolani, Milan, 1627).

    Google Scholar 

  3. 3

    Alitalo, K. & Carmeliet, P. Cancer Cell 1, 219–227 (2002).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  4. 4

    Ny, A. et al. Nat. Med. 11, 998–1004 (2005).

    CAS  Article  PubMed  Google Scholar 

  5. 5

    Wigle, J.T. et al. EMBO J. 21, 1505–1513 (2002).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  6. 6

    Wigle, J.T. & Oliver, G. Cell 98, 769–778 (1999).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. 7

    Fernyhough, M.E. et al. Tissue Cell 37, 335–338 (2005).

    CAS  Article  PubMed  Google Scholar 

  8. 8

    Rosen, E.D. Ann. NY Acad. Sci. 979, 143–58 (2002).

    CAS  Article  PubMed  Google Scholar 

  9. 9

    Kadowaki, T. & Yamauchi, T. Endocr. Rev. 26, 439–451 (2005).

    CAS  Article  PubMed  Google Scholar 

  10. 10

    Bagheri, S., Ohlin, K., Olsson, G. & Brorson, H. Lymphat. Res. Biol. 3, 66–80 (2005).

    Article  PubMed  Google Scholar 

  11. 11

    Nougues, J., Reyne, Y. & Dulor, J.P. Int. J. Obes. 12, 321–333 (1988).

    CAS  PubMed  Google Scholar 

  12. 12

    Karkkainen, M.J. et al. Proc. Natl. Acad. Sci. USA 98, 12677–12682 (2001).

    CAS  Article  PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Schneider, M., Conway, E. & Carmeliet, P. Lymph makes you fat. Nat Genet 37, 1023–1024 (2005). https://doi.org/10.1038/ng1005-1023

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing