Lymph makes you fat

A new study of mice lacking Prox1, a gene required for the formation of lymphatic endothelial cells, unveils a link between lymph fluid and fat deposition. These findings bring the lymphatic vascular system into the focus of obesity research.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Defects in lymphatic vasculature promote obesity.

References

  1. 1

    Harvey, N. et al. Nat. Genet. 37, 1072–1081 (2005).

  2. 2

    Asellius, G. in De Lacteibus sive lacteis venis Quarto Vasorum mesaroicum genere novo invente Gasp (Mediolani, Milan, 1627).

  3. 3

    Alitalo, K. & Carmeliet, P. Cancer Cell 1, 219–227 (2002).

  4. 4

    Ny, A. et al. Nat. Med. 11, 998–1004 (2005).

  5. 5

    Wigle, J.T. et al. EMBO J. 21, 1505–1513 (2002).

  6. 6

    Wigle, J.T. & Oliver, G. Cell 98, 769–778 (1999).

  7. 7

    Fernyhough, M.E. et al. Tissue Cell 37, 335–338 (2005).

  8. 8

    Rosen, E.D. Ann. NY Acad. Sci. 979, 143–58 (2002).

  9. 9

    Kadowaki, T. & Yamauchi, T. Endocr. Rev. 26, 439–451 (2005).

  10. 10

    Bagheri, S., Ohlin, K., Olsson, G. & Brorson, H. Lymphat. Res. Biol. 3, 66–80 (2005).

  11. 11

    Nougues, J., Reyne, Y. & Dulor, J.P. Int. J. Obes. 12, 321–333 (1988).

  12. 12

    Karkkainen, M.J. et al. Proc. Natl. Acad. Sci. USA 98, 12677–12682 (2001).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading