Ischemic stroke is a late-onset, complex polygenic disease, and it has proven difficult to identify its genetic determinants. A new study from Iceland shows that the gene encoding phosphodiesterase 4D is the most likely positional and pathophysiological candidate underlying the stroke susceptibility locus on chromosome 5q12.
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Dominiczak, A., McBride, M. Genetics of common polygenic stroke. Nat Genet 35, 116–117 (2003). https://doi.org/10.1038/ng1003-116
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DOI: https://doi.org/10.1038/ng1003-116
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