A Hopscotch-chromatin connection

Dysregulation of the JAK-STAT pathway is implicated in human cancer and leads to a hematopoietic tumor phenotype in flies. Now, an enhancer-suppressor screen of the fly tumor model connects the JAK kinase Hopscotch pathway with chromatin-modifying proteins and heterochromatic gene silencing.

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Figure 1: In the classic JAK-STAT pathway (darker background shading), Upd activates DOME, HOP activates STAT, and STAT translocates to the nucleus and activates transcription site-specifically.

Kim Caesar

References

  1. 1

    Wilks, A.F. Proc. Natl. Acad. Sci. USA 86, 1603–1607 (1989).

  2. 2

    Wilks, A.F. et al. Mol. Cell. Biol. 11, 2057–2065 (1991).

  3. 3

    Darnell, J.E. Jr., Kerr, I.M. & Stark, G.M. Science 264, 1415–1421 (1994).

  4. 4

    Hanratty, W.P. & Ryerse, J.S. Dev. Biol. 83, 238–249 (1981).

  5. 5

    Perrimon, N. & Mahowald, A.P. Dev. Biol. 118, 28–41 (1986).

  6. 6

    Binari, R. & Perrimon, N. Genes Dev. 8, 300–312 (1994).

  7. 7

    Luo, H., Hanratty, W.P. & Dearolf, C.R. EMBO J. 14, 1412–1420 (1995).

  8. 8

    Shi, S. et al. Nat. Genet. 38, 1071–1076 (2006).

  9. 9

    Yan, R., Luo, H., Darnell, J.E., Jr. & Dearolf, C.R. Proc. Natl. Acad. Sci. USA 93, 5842–5847 (1996).

  10. 10

    Levy, D. & Darnell, J.E. Jr . Nat. Rev. Mol. Cell Biol. 3, 651–662 (2002).

  11. 11

    Volpi, E.V. et al. J. Cell Sci. 113, 1565–1576 (2000).

  12. 12

    Zakharova, N. et al. J. Biol. Chem. 278, 43067–43073 (2003).

  13. 13

    O'Shea, J.J., Gadina, M. & Schreiber, R.D. Cell 109 (Suppl.), S121–s131 (2002).

  14. 14

    Kaur, S., Uddin, S. & Platanias, L.C. J. Interferon Cytokine Res. 25, 780–787 (2005).

  15. 15

    Katsoulidis, E., Li, Y., Mears, H. & Platanias, L.C. J. Interferon Cytokine Res. 25, 749–756 (2005).

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Betz, A., Darnell, J. A Hopscotch-chromatin connection. Nat Genet 38, 977–979 (2006) doi:10.1038/ng0906-977

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