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A Hopscotch-chromatin connection

Nature Genetics volume 38, pages 977–979 (2006)Cite this article

Dysregulation of the JAK-STAT pathway is implicated in human cancer and leads to a hematopoietic tumor phenotype in flies. Now, an enhancer-suppressor screen of the fly tumor model connects the JAK kinase Hopscotch pathway with chromatin-modifying proteins and heterochromatic gene silencing.

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Figure 1: In the classic JAK-STAT pathway (darker background shading), Upd activates DOME, HOP activates STAT, and STAT translocates to the nucleus and activates transcription site-specifically.

Kim Caesar

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  1. Laboratory of Molecular Cell Biology, The Rockefeller University, New York, 10021, New York, USA

    Aurel Betz & James E Darnell Jr

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  1. Aurel Betz
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  2. James E Darnell Jr
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Betz, A., Darnell, J. A Hopscotch-chromatin connection. Nat Genet 38, 977–979 (2006). https://doi.org/10.1038/ng0906-977

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