Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

An ICE pattern crystallizes

Identification of a new imprinting control element (ICE) on mouse chromosome 12 brings the total to five. Common features of imprinting mechanisms suggest a general model of ICE function.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: ICE action on the non-imprinted and imprinted chromosome.

References

  1. Wilkins, J.F. & Haig, D. Nat. Rev. Genet. 4, 359–368 (2003).

    Article  CAS  Google Scholar 

  2. Jaenisch, R. & Bird, A. Nat. Genet. 33, 245–254 (2003).

    Article  CAS  Google Scholar 

  3. Rand, E. & Cedar, H. J. Cell. Biochem. 88, 400–407 (2003).

    Article  CAS  Google Scholar 

  4. Li, E. Nat. Rev. Genet. 3, 662–673 (2002).

    Article  CAS  Google Scholar 

  5. Lin, S-P. et al. Nat. Genet. 35, 97–102 (2003).

    Article  CAS  Google Scholar 

  6. Leighton, P.A., Ingram, R.S., Eggenschwiler, J., Efstratiadis, A. & Tilghman, S.M. Nature 375, 34–39 (1995).

    Article  CAS  Google Scholar 

  7. Zwart, R., Sleutels, F., Wutz, A., Schinkel, A.H. & Barlow, D.P. Genes Dev. 15, 2361–2366 (2001).

    Article  CAS  Google Scholar 

  8. Fitzpatrick, G.V., Soloway, P.D. & Higgins, M.J. Nat. Genet. 32, 426–431 (2002).

    Article  CAS  Google Scholar 

  9. Nicholls, R.D. & Knepper, J.L. Annu. Rev. Genomics Hum. Genet. 2, 153–175 (2001).

    Article  CAS  Google Scholar 

  10. Bielinska, B. et al. Nat. Genet. 25, 74–78 (2000).

    Article  CAS  Google Scholar 

  11. Arney, K.L. Trends Genet. 19, 17–23 (2003).

    Article  CAS  Google Scholar 

  12. Sleutels, F., Tjon G., Ludwig, T. & Barlow, D.P. EMBO J. 22, 3696–3704 (2003).

    Article  CAS  Google Scholar 

  13. Wolffe, A.P. Curr. Biol. 10, R463–R465 (2000).

    Article  CAS  Google Scholar 

  14. Schmidt, J.V., Levorse, J.M. & Tilghman, S.M. Proc. Natl. Acad. Sci. USA 96, 9733–9738 (1999).

    Article  CAS  Google Scholar 

  15. Sleutels, F., Zwart, R. & Barlow, D.P. Nature 415, 810–813 (2002).

    Article  CAS  Google Scholar 

  16. Rougeulle, C. & Heard, E. Trends Genet. 18, 434–437 (2002).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank I. Yotova and S. Stricker for reading the manuscript.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spahn, L., Barlow, D. An ICE pattern crystallizes. Nat Genet 35, 11–12 (2003). https://doi.org/10.1038/ng0903-11

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0903-11

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing