Certain human cancers and carcinogen-induced rodent tumors commonly contain Kras2 mutations. This activated form of ras has always been described as a dominant oncogene. A new study indicates that wildtype Kras2 has properties of a tumor suppressor gene and may have the capacity to reduce the transforming potential of oncogenically activated ras.
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Pfeifer, G. A new verdict for an old convict. Nat Genet 29, 3–4 (2001). https://doi.org/10.1038/ng0901-3
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DOI: https://doi.org/10.1038/ng0901-3
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