A new study reports the first mouse model for ATR-mutated Seckel syndrome. The mice show phenotypes recapitulating the human disorder and provide insights into how reduced ATR function affects normal embryonic development by increasing replicative stress, ultimately resulting in an accelerated aging phenotype postnatally.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Murga, M. et al. Nat. Genet. 41, 891–898 (2009).
Brown, E.J. & Baltimore, D. Genes Dev. 14, 397–402 (2000).
de Klein, A. et al. Curr. Biol. 10, 479–482 (2000).
O'Driscoll, M., Ruiz-Perez, V.L., Woods, C.G., Jeggo, P.A. & Goodship, J.A. Nat. Genet. 33, 497–501 (2003).
Seckel, H.P.G. Bird-Headed Dwarfs: Studies in Developmental Anthropology Including Human Proportions (Karger, Basel, 1960).
Griffith, E. et al. Nat. Genet. 40, 232–236 (2008).
Alderton, G.K. et al. Hum. Mol. Genet. 13, 3127–3138 (2004).
O'Driscoll, M. & Jeggo, P.A. DNA Repair (Amst.) 7, 1039–1050 (2008).
Ruzankina, Y. et al. Cell Stem Cell 1, 113–126 (2007).
Garinis, G.A. et al. Nat. Cell Biol. 11, 604–615 (2009).
Fang, Y. et al. EMBO J. 23, 3164–3174 (2004).
Lam, M.H., Liu, Q., Elledge, S.J. & Rosen, J.M. Cancer Cell 6, 45–59 (2004).
Shima, N. et al. Nat. Genet. 39, 93–98 (2007).
Wang, Y. et al. Nat. Genet. 37, 750–755 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
O'Driscoll, M. Life can be stressful without ATR. Nat Genet 41, 866–868 (2009). https://doi.org/10.1038/ng0809-866
Issue Date:
DOI: https://doi.org/10.1038/ng0809-866
