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One PRDM is not enough for germ cell development

Nature Genetics volume 40, pages 934–935 (2008)Cite this article

Developmentally regulated expression of the transcriptional repressor Prdm1 (Blimp1) in the early mammalian embryo controls global epigenetic changes required for specification of primordial germ cells. A new study demonstrates that a close family member, Prdm14, similarly activated in response to Bmp and Smad signals, also has an essential role during establishment of the germ cell lineage.

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Figure 1: Master regulators of germ cell fate.

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Authors and Affiliations

  1. Elizabeth K. Bikoff and Elizabeth J. Robertson are at the Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. elizabeth.robertson@path.ox.ac.uk,

    Elizabeth K Bikoff & Elizabeth J Robertson

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  1. Elizabeth K Bikoff
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  2. Elizabeth J Robertson
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Bikoff, E., Robertson, E. One PRDM is not enough for germ cell development. Nat Genet 40, 934–935 (2008). https://doi.org/10.1038/ng0808-934

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