Nucleic acid by-products and chronic inflammation

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Aicardi-Goutières syndrome (AGS) is an autosomal recessive condition of progressive encephalopathy of early childhood, very similar to congenital viral infections. Two new papers identify four genes mutated in AGS and implicate the processing of DNA and RNA by-products in its pathogenesis.

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Figure 1: Proposed stimulation of the interferon pathway by RNA:DNA hybrids in AGS.

Kim Caesar

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Alarcón-Riquelme, M. Nucleic acid by-products and chronic inflammation. Nat Genet 38, 866–867 (2006) doi:10.1038/ng0806-866

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