A new study in mice shows that genetic variants underlying a previously mapped lung cancer susceptibility locus can have opposing effects on cancer risk depending on whether an oncogenic somatic mutation at the same locus subsequently arises in cis or in trans. These findings illustrate the complex interplay between genetic background and somatic events in contributing to cancer risk.
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Hunter, K. Context-dependent cancer risk. Nat Genet 38, 864–865 (2006). https://doi.org/10.1038/ng0806-864
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DOI: https://doi.org/10.1038/ng0806-864
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Biology of urothelial tumorigenesis: insights from genetically engineered mice
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