From worm genetic networks to complex human diseases

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Systematic mapping of genetic interactions for Caenorhabditis elegans genes involved in signaling pathways implicated in human disease reveals a network of 350 interactions. The topology of this network resembles that mapped previously in yeast, reinforcing the idea that similar networks may underlie the genetic basis of complex human disease.

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Bussey, H., Andrews, B. & Boone, C. From worm genetic networks to complex human diseases. Nat Genet 38, 862–863 (2006) doi:10.1038/ng0806-862

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