Systematic mapping of genetic interactions for Caenorhabditis elegans genes involved in signaling pathways implicated in human disease reveals a network of 350 interactions. The topology of this network resembles that mapped previously in yeast, reinforcing the idea that similar networks may underlie the genetic basis of complex human disease.
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References
Hartman, J.L., Garvik, B. & Hartwell, L. Science 291, 1001–1004 (2001).
Lehner, B., Crombie, C., Tischler, J. Fortunato, A. & Fraser, A.G. Nat. Genet. 38, 896–903 (2006).
Kamath, R.S. et al. Nature 421, 231–237 (2003).
Tong, A.H. et al. Science 303, 808–813 (2004).
Pan, X. et al. Cell 124, 1069–1081 (2006).
Rutherford, S.L. & Lindquist, S. Nature 396, 336–342 (1998).
Davierwala, A.P. et al. Nat. Genet. 37, 1147–1152 (2005).
Badano, J.L. & Katsanis, N. Nat. Rev. Genet. 3, 779–789 (2002).
Hartwell, L.H., Szankasi, P., Roberts, C.J., Murray, A.W. & Friend, S.H. Science 278, 1064–1068 (1997).
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Bussey, H., Andrews, B. & Boone, C. From worm genetic networks to complex human diseases. Nat Genet 38, 862–863 (2006). https://doi.org/10.1038/ng0806-862
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DOI: https://doi.org/10.1038/ng0806-862
